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EUBCE 2024 - Sarah DE SOUZA QUEIROZ - Exploring Xylose Transport Genes from Candida Tropicalis for Enhanced Biomass Conversion in Bioprocesses

Exploring Xylose Transport Genes from Candida Tropicalis for Enhanced Biomass Conversion in Bioprocesses

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Biorefineries processes and integration

Exploring Xylose Transport Genes from Candida Tropicalis for Enhanced Biomass Conversion in Bioprocesses

Short Introductive summary

The use of lignocellulosic biomass as a raw material in industrial bioprocesses is a promising strategy in the context of the circular economy. Specifically focusing on the hemicellulosic fraction, the deconstruction of this macromolecule results in hydrolysates rich in pentoses (C5), particularly xylose. However, Saccharomyces cerevisiae, one of the most widely used yeasts in industrial fermentation processes, is inefficient in assimilating xylose. Genetic engineering efforts aim to overcome this limitation, developing S. cerevisiae strains efficient in xylose bioconversion. Although improvements have been observed through the heterologous expression of Xylose Reductase (XR), Xylitol Dehydrogenase (XDH), and other enzymes of the pentose phosphate pathway in S. cerevisiae, optimal efficiency in xylose bioconversion requires the presence of transport proteins responsible for the assimilation and internalization of xylose into the yeast cell. This study is focused on naturally occurring yeast species capable of metabolizing C5 sugars as a model for the identification and characterizing of pentose transporters, which can improve xylose utilization.

Presenter

Sarah DE SOUZA QUEIROZ

Technical University of Denmark, DENMARK

Biographies and Short introductive summaries are supplied directly by presenters and are published here unedited


Co-authors:

S. Souza Queiroz, Technical University of Denmark, Kongens Lyngby, DENMARK
T. da Franca Silva, University of São Paulo, Lorena, BRAZIL
G. Henrique Goldman, University of São Paulo, Lorena, BRAZIL
M. das Graças de Almeida Felipe, University of São Paulo, Lorena, BRAZIL
S. Inês Mussatto, Technical University of Denmark, Kongens Lyngby, DENMARK

Session reference: 3CV.6.14